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| 334 BC |
| | | The 21-year-old Alexander the Great marches east with some 5000 cavalry and 30,000 footsoldiers | |
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| 334 BC |
| | | Indulging in a moment of romantic tourism, Alexander visits Troy at the start of his Persian campaign | |
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| 334 BC |
| | | At the river Granicus, not far from Troy, Alexander defeats a Persian army employing many Greek mercenaries | |
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| 333 BC |
| | | At Issus, close to the Turkish border with Syria, Alexander defeats the Persian emperor Darius III, captures his family and treats them with courtesy | |
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| 333 BC |
| | | At Gordium, in central Turkey, Alexander is credited with cutting the mythical Gordian Knot (identifying him as the ruler of Asia) | |
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| 332 BC |
| | | Alexander moves south through Syria and Palestine, excluding the Persian fleet from their familiar harbours | |
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| 332 BC |
| | | Tyre, the only coastal city to offer serious resistance to Alexander, is taken and destroyed after a siege of seven months | |
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| 332 BC |
| | | Alexander the Great's army arrives in Egypt and the Persian governor of the province rapidly surrenders | |
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| 332 BC |
| | | In Memphis Alexander sacrifices to Apis, a sacred bull, and is crowned pharaoh by the priests | |
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| 332 BC |
| | | While in Egypt, Alexander founds Alexandria – the best known of the many towns he establishes to spread Greek culture | |
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